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6-OXO is brought to you by the innovative company ergopharm.
6-OXO was the first effective all natural aromatase inhibitor available on the OTC supplement market.
Before I go into detail about 6-OXO, I would like to give a very brief review and commentary on the current variety of estrogen blocking supplements.
The first estrogen blocking supplement to be introduced, and perhaps the most popular one to date is the isoflavone chrysin. Yes, chrysin has some good in-vitro (”test tube”) research on it that demonstrates it blocks aromatase. However, for years many experts including myself have contended that it suffers from very poor bioavailability, and therefore is ineffective in-vivo. Recently, an article has been published in a very reputable journal that substantiates this suspicion.1 So chrysin, as promising as it once seemed, unfortunately appears to be a total bust.
After chrysin there was Indole-3-carbinol and Di-indoylmethane. These related compounds work by shifting the metabolism of estrogens away from strong estrogen compounds (16-hydroxylated) and towards weaker estrogens (2-hydroxylated). This can have benefits for women prone to breast cancer as 16-hydroxylated estrogens are quite notorious for promoting estrogen dependent breast cancer. However, there has never been any benefit demonstrated in men for reducing estrogen related effects or for increasing androgen levels. In fact, these compounds may actually REDUCE androgen levels.2 So for males looking to reduce estrogen and raise testosterone, I-3-C and DIM are poor choices.
In addition to these aforementioned compounds there have been a slew of other compounds sold for estrogen control purposes. These include bioflavonoids such as quercitin, herbs such as Vitex Agnus Castus, and phytochemicals such as resveratrol (3,5,4′-trihydroxystilbene). None of these has ever been substantiated by any research to reduce estrogen levels or to increase testosterone levels.
After years of research into natural estrogen blockers I finally discovered a compound that really truly works, in males, to both reduce estrogen and increase testosterone. Its called 6-OXO, which is short for 3,6,17-androstenetrione.
6-OXO is what is known as a suicide inhibitor of aromatase. This means that 6-OXO binds to the aromatase enzyme in a permanent and irreversible manner, rendering it inactive. The result of this is an eventual diminishment of aromatase enzyme in the body and a concomitant reduction in estrogen levels.3 4 5 6 7 A corresponding increase in testosterone production is usually experienced as well. 8
It is important to note here that this deactivation of aromatase enzymes by 6-OXO does not mean that your body becomes permanently deficient in the ability to synthesize estrogen. Your body will react to the deficiency of enzyme by producing more enzyme to replace that which has been deactivated. Therefore, when you stop taking 6-OXO your aromatase enzyme level will quickly catch up to normal and full estrogen production will resume.
6-OXO is all natural as it is known to be an androgen metabolite formed in the adrenal9 and placenta.10
When and how you should use 6-OXO
There are two main situations where 6-OXO can come in useful. The first situation is in combating estrogen elevation while taking aromatizable prohormones or steroids. Aromatizable prohormones/ steroids include testosterone, testosterone precursors (4-androstenedione, 4-androstenediol), nortestosterone, nortestosterone precursors (19-nor-4-androstenedione, 19-nor-4-androstenediol), and synthetic anabolic steroids such as oxymetholone (Anadrol) and methandrostenolone (Dianabol).
The second situation where 6-OXO stands very useful is in restoring full endogenous testosterone production after a cycle of prohormones or steroids. Prohormones and steroids act as replacements for natural testosterone, and as a consequence, prolonged usage of these substances results in the body resetting the level of its own natural testosterone production. Your body does this by adjusting the activity of the hypothalamic pituitary testicular axis, or HPTA. The HPTA acts like a thermostat that constantly adjusts the body’s production of testosterone to maintain a certain level in the blood. The hypothalamus is the primary sensor in this system, and it responds to both androgens (i.e. testosterone, DHT) and estrogens (derived from aromatization of androgens). The hypothalamus is so sensitive to estrogens in fact that administration of an estrogen blocker can often result in a very substantial surge in testosterone production. This is why steroid using bodybuilders take products such as Clomiphene (an estrogen receptor antagonist) and Anastrazole (an aromatase inhibitor) after cycles to jump-start their suppressed testicular testosterone production. Now, with the introduction of 6-OXO, there is a natural - over the counter alternative available to these prescription only drugs.
Okay, am I saying that one has to be a prohormone or steroid user to find 6-OXO useful? Certainly not! Even if you never touch prohormones/steroids you can obtain a very substantial and beneficial increase in natural testosterone production by taking nothing but 6-OXO. For those that are wary of hormonal supplements and their effects on the bodies endocrine balance, yet still want to obtain the benefits of increased testosterone levels, 6-OXO offers a very safe and effective alternative.
So how does one use 6-OXO? If you are using it to combat estrogen during a cycle of aromatizable steroids then you can take it every day of your cycle, once a day (preferably with your evening meal) at a dosage of 200-600 mg. If you are using it to jump-start your testosterone production after a cycle of prohormones (or just to increase your own natural production in a clean state) then you would also take 200-600mg of 6-OXO once a day, for a period of 3-6 weeks.
If you are a prohormone user, or even a steroid user, I doubt I have to entice you anymore than I have to give this stuff a try. The research is solid, and the product is affordable. This is the first new product that Ergopharm has introduced in over a year, and I am sure you will soon discover for yourselves that 6-OXO is a product well worth the wait!!
6-OXO Facts:
Serving Size: 3 Capsules
Servings Per Container: 20
Amount Per Serving:
6-OXO (delta-4-10, 13-dimethyl-cyclopenta[a]phenantrene-3,6,17-trione): 300 mg
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