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IBE Epistane is finally the PRO-Anabolic, anti-estrogen we have all been waiting for has arrived! Epistane, exhibits a strong, long lasting anti-estrogen effect that is organ tissue specific. This means it works only where you want it to work. Broad range estrogen blockers and aromatase inhibitors can result in system shut down, aching joints, and decreased IGF-I expression. Epistane binds specifically to the 17-estradiol receptor protein in the target tissues. Because of its long lasting and strong effects on specific tissue, Epistane can significantly reduce and reverse the effects of gynocomastia because not only does Epistane specifically block estrogen in breast tissue but it induces an estrogen-depleted condition which leads to apoptosis or the death of the breast tissue cells. Studies show that small doses of the parent compound, Epitiostanol, at just 10-20mg/week showed a complete disappearance of the mass and pain in 25% of the male patients in the clinical trail, while the other 75% of the patients showed at least a 50% reduction in the mass and complete loss of pain in just 4-8 weeks. Thats results in 100% of the male users with no side effects. While compounds such as Clomid and Nolvadex also block the 17-estradiol receptor, they do not elicit the same increase in protein synthesis and strength gains that Epistane can offer.
Epistane is more than an anti-estrogen, though, as it also binds to androgen receptors in skeletal muscle. As a PRO-Anabolic compound Epistane promotes increases in strength and lean body mass with an anabolic/androgenic value (Q ratio) of 12. With most powerful androgens there is a high risk of the natural suppression of the gonads. Epistane, unlike other PRO-Anabolic compounds that have recently been released, is relatively mild on the gonads and, due to the anti-estrogenic effects and the fact that Epistane keeps LH levels elevated, post cycle therapy becomes a breeze. All effects combined make Epistane a great compound to produce dry, lean gains in muscle mass with minimal side effects and suppression of the bodys natural androgen production, while lowering the effects of natural estrogen or combating estrogen from endogenous/exogenous sources. This makes it a powerful tool when combined with wet compounds in attempt to increase gains and decrease side effects. One can also not overlook the potential benefit of this compound taken alone, especially when recovering from periods of wet compounds. If you dont want to worry about how your lipid and liver values are doing and whether or not you are going to get gynocomastia or not then get Epistane, stop worrying, and experience what others are raving about!
Epistane Effects:
-Incredible Strength Gains
-Dry, Lean Mass Gains
-Gynocomastia Protection
-Increased Libido
-Increased Training Intensity and Sense of Well-Being
-In Some, Reductions in Gynocomastia!
How Epistane Works
Battling Gyno
Estradiol is the strongest form of estrogen in the human body, effecting several organs. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Epistane works by binding and deactivating the ER so that no estrodiol-elicited effects can be carried out in the cell. In the case of breast tissue ER is the primary target receptor responsible for growth and proliferation. Epistane binds to the ER and not only disables the receptor from binding to estradiol, it actually puts the cell in an estrogen deprived state, which decreases the cells viability and leads to a decrease in size and eventual cell death. Other SERMs also block the ER receptor and AIs even block the formation of Estradiol from testosterone conversion. However, the effectiveness at the receptor and long term side effects vary. Epistane has been shown to have one of the strongest and longest effects at the binding site, with minimal side effects when compared to other anti-estrogens.
Increasing Lean Body Mass
Epistane also binds to androgen receptors located on skeletal muscle cells and muscle stem cells. This then leads to changes in muscle cell function and protein synthesis. In the case of muscle stem cells, they will actually change and fuse with your active adult skeletal muscles increasing the muscles potential for growth and repair. On the opposing side, the presence of androgens actually decreases the ability of stem cells to form new fat cells. So you now have increased stem cell conversion to muscle cells and decreased stem cell conversion to fat cells, giving you more positive effects out of your nutrition and training.
Epistane Facts:
Serving Size: 1 capsule
Servings per Container: 90
Amount Per Serving:
2,3a-Epithio-17a-methyletioallo cholan-17b-ol 10 mg
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